Cmax and Cmin levels of tolterodine extended release are about 75% and 150% of tolterodine immediate release, respectively.
As a sedative when used as premedication and following general anesthesia, Hydroxyzine may potentiate meperidine (DemerolВ®) and barbiturates, so their use in pre-anesthetic adjunctive therapy should be modified on an individual basis.
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This drug is known to be substantially excreted by the kidney and the risk of toxic reactions to this drug may be greater in patients with impaired renal function.
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Borderline elevations of one or more liver tests may occur in up to 15% of patients taking NSAIDs including etodolac.
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