Administration of doses of NUROMAX up to and including 0.08 mg/kg (~3 Г— ED95) over 5 to 15 seconds to healthy adult patients during stable-state balanced anesthesia and to patients with serious cardiovascular disease undergoing coronary artery bypass grafting, cardiac valvular repair, or vascular repair produced no dose-related effects on mean arterial blood pressure (MAP) or heart rate (HR).
IN THIS ARTICLESjögren Syndrome OverviewSjögren Syndrome CausesSjögren Syndrome SymptomsWhen to Seek Medical CareExams and TestsSjögren Syndrome TreatmentSelf-Care at HomeMedical TreatmentMedicationsSurgeryNext StepsFollow-upPreventionOutlookSupport Groups and CounselingFor More InformationWeb LinksSynonyms and KeywordsAuthors and EditorsPictures of Rheumatoid Arthritis - Slideshow Viewer Comments: Sjogren Syndrome - Describe Your ExperienceSjögren Syndrome CausesThe cause of Sjögren syndrome is not known.
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Adverse events associated with SKELID usually have been mild, and generally have not required discontinuation of therapy.
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Benign and/or malignant transitional cell neoplasms were observed in male rats at 4В mg/kg/day and above (approximately equal to the maximum recommended human oral dose based on mg/m2). A two-year carcinogenicity study was conducted in male and female mice at oral doses up to 100В mg/kg/day (approximately 11 times the maximum recommended human oral dose based on mg/m2). No drug-induced tumors were observed in any organ.
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For example, patients taking enzyme-inducing antiepileptic drugs (carbamazepine, phenytoin, and phenobarbital) will clear valproate more rapidly.