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Always take Accutane with a full glass of water to prevent the capsule from melting in your esophagus (food pipe), causing irritation. Do not chew or suck on the capsule. Swallow it as quickly as possible. Take Accutane with food or milk. Take this medication for the entire length of time of your treatment. Your acne may seem to get worse at first, but should then begin to improve.
The dose of Accutane is dependent on your weight and the severity of the condition. High dose treatments are administered between 0.5 mg/kg/day to 2 mg/kg/day, for a total treatment of 4-6 months. In some rare cases the initial course may last up to 9 months. A second course may be used at least 8 weeks following the cessation of the initial course if severe acne recurs. Efficacy appears to be related to the cumulative dose of Accutane taken, with a total cumulative dose of 120-150 mg/kg used as a guideline.

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