These irritated muscles contract in excess, like a rubber band that closes the air tubes even further.
The first and second doses were 1000 mg/m2 and the third dose was 500 mg/m2. No dose modifications were planned except for patients whose body surface area exceeded 2.0В m2, in which case the total daily dose limit on the first and second day was 2000 mg/day and 1000 mg on the third day.
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Establishing a relationship with a primary care provider will allow appropriate monitoring of specific disease states, regulating medications and diet to help prevent acute flares of encephalopathy, and decrease the potential for gradual decline in mental function.