Thyroid hormones are also metabolized via conjugation with glucuronides and sulfates and excreted directly into the bile and gut where they undergo enterohepatic recirculation.
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Lubeluzole was tested in several clinical trials, including one that evaluated the combination of the medication and rtPA.
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Evaluation of published reports of leukemia developing in patients who have received chlorambucil (and other alkylating agents) suggests that the risk of leukemogenesis increases with both chronicity of treatment and large cumulative doses.
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The term amenorrhea is usually used to refer to women who should be having menstrual periods but do not.
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Guideline development has limitations related to the generalizability of results from one population to another.
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Even minor injuries can result in serious infections.
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The pharmacokinetics of fosphenytoin following IV administration of fosphenytoin sodium injection, however, are complex, and when used in an emergency setting (eg, status epilepticus), differences in rate of availability of phenytoin could be critical.
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A determination has not been made whether controlled clinical studies of doxepin included sufficient numbers of subjects aged 65 and over to define a difference in response from younger subjects.
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Throughout both procedures, doctors monitor breathing, heart rate, and pain.