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A study was conducted in which the blood pressure and heart rate response to 0.4 mg nitroglycerin (NTG) sublingually was evaluated in 18 healthy subjects following pretreatment with LEVITRA (vardenafil hcl) 20 mg at various times before NTG administration. LEVITRA (vardenafil hcl) 20 mg caused an additional time-related reduction in blood pressure and increase in heart rate in association with NTG administration. The blood pressure effects were observed when LEVITRA (vardenafil hcl) 20 mg was dosed 1 or 4 hours before NTG and the heart rate effects were observed when 20 mg was dosed 1, 4, or 8 hours before NTG. Additional blood pressure and heart rate changes were not detected when LEVITRA (vardenafil hcl) 20 mg was dosed 24 hours before NTG. (See Figure 2.)
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