Pernicious anemia is easily and effectively treated by the administration of vitamin B-12. Lifelong treatment is required.
Gender Gender differences in theophylline clearance are relatively small and unlikely to be of clinical significance.
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In people with paroxysmal nocturnal hemoglobinuria, however, abnormal red blood cells are missing two important complement-regulating proteins that need the GPI anchor protein to attach them to the cell membrane.
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As with any drug given over prolonged periods, laboratory parameters should be monitored at regular intervals.
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