In addition, some nelarabine is hydrolyzed to form methylguanine, which is O-demethylated to form guanine.
Because animal reproduction studies are not always predictive of human response and in view of the desirability of keeping the administration of all drugs to a minimum during pregnancy, this drug should be used only if clearly needed.
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Glycosylated hemoglobin is formed by the non-enzymatic linkage of glucose and the free amino groups of lysine and valine residues in hemoglobin.
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Use of filter devices such as IVEX-2В® filters which incorporate short inlet and outlet PVC-coated tubing has not resulted in significant leaching of DEHP.
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