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Tetracycline gan , , included 46 healthy, overweight men and women (average age 37) assigned to one of four groups: The 11 participants in the control group ate a healthy diet; 12 others consumed 25 percent fewer calories than they expended per day; 12 created a 25 percent energy deficit by eating fewer calories and exercising five days a week; and 11 people ate a low-calorie diet (890 calories) a day until they achieved a 15 percent weight loss, at which time they switched to a weight maintenance plan.
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